Substandard
Substandard, inferior, second-class, inadequate, not up to scratch, deficient, defective, shoddy, careless, dreadful, terrible, frightful, disgraceful, hopeless, laughable, miserable, third-rate, execrable, inept, ineffectual, rotten, useless, bum, appalling, pitiful, dire, the pits, chronic, pants, ropy, egregious, poor, second-rate, unsatisfactory, unacceptable, not up to par, imperfect, faulty, amateurish, negligent, awful, abominable, atrocious, deplorable, worthless, lamentable, sorry, diabolical, incompetent, inexpert, crummy, pathetic, woeful, lousy, abysmal, godawful, not up to snuff, duff, rubbish, a load of pants, and poxy.
Inauspicious
Inauspicious, adverse, inopportune, inappropriate, unfavourable, untoward, disadvantageous, difficult, unpropitious, unsuitable, unfortunate, and disastrous.
Unpleasant
Unpleasant, unwelcome, unfavourable, adverse, terrible, awful, distressing, parlous, disagreeable, unfortunate, unlucky, nasty, dreadful, grim, and regrettable.
Severe
Severe, grave, grievous, dreadful, awful, dire, frightful, life-threatening, serious, critical, acute, terrible, ghastly, grim, shocking, and peracute.
Harmful
Harmful, detrimental, injurious, inimical, destructive, deleterious, unwholesome, damaging, undesirable, hurtful, dangerous, ruinous, and unhealthy.
Wicked
Wicked, immoral, morally wrong, base, depraved, dissolute, criminal, nefarious, dishonest, unscrupulous, crooked, dirty, sinful, evil, corrupt, reprobate, degenerate, amoral, villainous, iniquitous, dishonourable, unprincipled, bent, and dastardly.
Injured
Injured, diseased, knackered, game, wounded, gammy, and crook.
Ill
Ill, sick, ailing, sickly, afflicted, infirm, out of sorts, not in good shape, under/below par, bedridden, on the sick list, queasy, nauseated, feeble, diseased, off colour, not up to snuff, funny, iffy, lousy, groggy, at death's door, ropy, dicky, crook, seedy, unwell, not (very) well, poorly, peaky, indisposed, liverish, not oneself, not up to par, in a bad way, invalided, valetudinarian, nauseous, weak, frail, infected, under the weather, laid up, peculiar, crummy, rough, green around the gills, like death warmed up, grotty, wabbit, and queer.
Rotten
Rotten, decayed, decomposing, putrefied, mouldy, sour, rank, addled, worm-eaten, flyblown, putrefacient, off, decomposed, putrid, putrescent, mouldering, rancid, unfit for human consumption, maggoty, wormy, and putrefactive.
Guilty
Guilty, remorseful, ashamed, contrite, full of regret, repentant, shamefaced, apologetic, conscience-stricken, guilt-ridden, chastened, sorry, regretful, penitent, and self-reproachful.