Despair
Anguish
Synonyms Hopelessness, distress, pain, dejection, despondency, gloom, melancholia, wretchedness, discouragement, forlornness, pessimism, desperation, anguish, unhappiness, depression, disconsolateness, melancholy, misery, disheartenment, resignedness, and defeatism.
Lose heart
Synonyms Lose hope, abandon hope, lose heart, be despondent, resign oneself, quit, be pessimistic, despond, desperate, distressed, heartbroken, inconsolable, suicidal, dejected, despondent, gloomy, miserable, desolate, disheartened, demoralized, downcast, defeatist, dolorous, give up hope, give up, be discouraged, be demoralized, throw in the towel/sponge, surrender, look on the black side, hopeless, anguished, broken-hearted, grief-stricken, sorrowing, in despair, depressed, disconsolate, melancholy, wretched, forlorn, discouraged, devastated, resigned, and pessimistic.
Example Sentences
He felt overwhelmed by despair yesterday.
Despair clouded her thoughts completely.
They struggled through moments of despair.
In despair, she sought comfort.