Trouble
Problems
Synonyms: Problems, issues, inconvenience, anxiety, concern, unease, vexation, stress, harassment, hassle, misfortune, trial, trauma, hardship, pain, affliction, woe, unhappiness, heartache, travails, in difficulties, in a mess, in a predicament, heading for disaster, in shtook, in a fix, in hot water, in a pickle, screwed, up a gum tree, difficulty, bother, worry, distress, disquiet, irritation, annoyance, agitation, unpleasantness, problem, issue, tribulation, adversity, burden, suffering, torment, grief, sadness, misery, in difficulty, having problems, in a bad way, in dire/desperate straits, heading for the rocks, in a tight corner/spot, in a hole, in a jam, in the soup, and up against it.
Disease
Synonyms: Disease, sickness, complaint, disorder, dysfunction, failure, fault, illness, ailment, problem, disability, malfunction, and breakdown.
Bother
Synonyms: Bother, fuss, exertion, labour, care, thought, inconvenience, effort, work, pains, attention, and hassle.
Nuisance
Synonyms: Nuisance, inconvenience, irritant, trial, cause of annoyance, thorn in someone's flesh/side, pain in the neck, pain in the backside, bore, burr in/under someone's saddle, fair cow, bother, irritation, problem, pest, source of difficulty, headache, pain, drag, pain in the butt, and nudnik.
Shortcoming
Synonyms: Shortcoming, weak point, fault, defect, problem, weakness, failing, imperfection, blemish, and difficulty.
Disturbance
Synonyms: Disturbance, unrest, fighting, conflict, commotion, uproar, fracas, brouhaha, breach of the peace, to-do, hullabaloo, disorder, bother, scuffling, tumult, turbulence, ructions, rumpus, furore, affray, hoo-ha, and kerfuffle.
Worry
Synonyms: Worry, cause concern to, disturb, make anxious, make uneasy, distress, alarm, annoy, vex, torment, nag, gnaw at, oppress, burden, perplex, bug, bother, concern, upset, make uncomfortable, agitate, grieve, perturb, irritate, irk, plague, niggle, prey on someone's mind, weigh down, afflict, and puzzle.
Be anxious
Synonyms: Be anxious, be concerned, worry, fret, be distressed, concern oneself, upset oneself, and agonize.
Be afflicted with/by
Synonyms: Be afflicted with/by, be beset with/by, be incapacitated with, be cursed with, be a martyr to, be bedevilled by, be dogged by, be racked with, suffer from, and ail with.
Inconvenience
Synonyms: Inconvenience, bother, create difficulties for, put out, hassle, incommode, cause inconvenience to, impose on, disturb, disoblige, and discommode.
Bother
Synonyms: Bother, go to the trouble, exert oneself, take the trouble/time, make the effort, and go out of one's way.
Example Sentences
He ran into trouble at school.
She is always getting into trouble.
The engine is having some trouble.
They were in serious trouble.
Don’t get yourself into trouble.
He had trouble sleeping last night.
She avoided trouble by staying quiet.
I’m having trouble understanding this.
He’s known for causing trouble.
They had trouble finding the place.
