Trouble
Problems
Synonyms Problems, issues, inconvenience, anxiety, concern, unease, vexation, stress, harassment, hassle, misfortune, trial, trauma, hardship, pain, affliction, woe, unhappiness, heartache, travails, in difficulties, in a mess, in a predicament, heading for disaster, in shtook, in a fix, in hot water, in a pickle, screwed, up a gum tree, difficulty, bother, worry, distress, disquiet, irritation, annoyance, agitation, unpleasantness, problem, issue, tribulation, adversity, burden, suffering, torment, grief, sadness, misery, in difficulty, having problems, in a bad way, in dire/desperate straits, heading for the rocks, in a tight corner/spot, in a hole, in a jam, in the soup, and up against it.
Disease
Synonyms Disease, sickness, complaint, disorder, dysfunction, failure, fault, illness, ailment, problem, disability, malfunction, and breakdown.
Bother
Synonyms Bother, fuss, exertion, labour, care, thought, inconvenience, effort, work, pains, attention, and hassle.
Nuisance
Synonyms Nuisance, inconvenience, irritant, trial, cause of annoyance, thorn in someone's flesh/side, pain in the neck, pain in the backside, bore, burr in/under someone's saddle, fair cow, bother, irritation, problem, pest, source of difficulty, headache, pain, drag, pain in the butt, and nudnik.
Shortcoming
Synonyms Shortcoming, weak point, fault, defect, problem, weakness, failing, imperfection, blemish, and difficulty.
Disturbance
Synonyms Disturbance, unrest, fighting, conflict, commotion, uproar, fracas, brouhaha, breach of the peace, to-do, hullabaloo, disorder, bother, scuffling, tumult, turbulence, ructions, rumpus, furore, affray, hoo-ha, and kerfuffle.
Worry
Synonyms Worry, cause concern to, disturb, make anxious, make uneasy, distress, alarm, annoy, vex, torment, nag, gnaw at, oppress, burden, perplex, bug, bother, concern, upset, make uncomfortable, agitate, grieve, perturb, irritate, irk, plague, niggle, prey on someone's mind, weigh down, afflict, and puzzle.
Be anxious
Synonyms Be anxious, be concerned, worry, fret, be distressed, concern oneself, upset oneself, and agonize.
Be afflicted with/by
Synonyms Be afflicted with/by, be beset with/by, be incapacitated with, be cursed with, be a martyr to, be bedevilled by, be dogged by, be racked with, suffer from, and ail with.
Inconvenience
Synonyms Inconvenience, bother, create difficulties for, put out, hassle, incommode, cause inconvenience to, impose on, disturb, disoblige, and discommode.
Bother
Synonyms Bother, go to the trouble, exert oneself, take the trouble/time, make the effort, and go out of one's way.
Example Sentences
He ran into trouble at school.
She is always getting into trouble.
The engine is having some trouble.
They were in serious trouble.
Don’t get yourself into trouble.
He had trouble sleeping last night.
She avoided trouble by staying quiet.
I’m having trouble understanding this.
He’s known for causing trouble.
They had trouble finding the place.